PRESENTATION

Scientific talent responds to society for the results obtained with the donations made to La Marató

Five years ago, La Marató de TV3 and Catalunya Ràdio focused on neurodegenerative diseases with the aim of boosting research to find responses to conditions that are highly debilitating but still have no cure and the causes of which are unknown.

The slogan of that edition, "Solidarity does not degenerate" was made clear in the sum of 11.8 million euros that was raised thanks to the participation of the public on that occasion in December 2013. The 15 hours of live television led by Nuria Solé and Roger de Gràcia, and the six hours on radio hosted by Sílvia Cóppulo, were filled by the personal experiences of people who live with a neurodegenerative disease and those of their families, by contributions from doctors and researchers, by music and entertainment, and by connections with all parts of Catalonia, where members of the public took part in thousands of activities.

After that explosion of celebration and solidarity there have been years of hard, rigorous work by the 79 scientific teams that received grants to run the 44 funded research projects, of which 23 were in single centres and 21 were co-ordinated. These projects were chosen from among the 187 that responded to the invitation for applications in an evaluation process that was co-ordinated by the Catalan Agency for Health Technology Assessment and Research (AQuAS) and in which 96 international experts in neurodegenerative diseases assessed their quality, methodology, scientific, health and social relevance, innovative value and viability.

The Fundación La Marató de TV3 is now holding its 20th Symposium to present the results of this intense research activity that have been translated into new tools for prevention and of diagnosis, as well as new therapeutic approaches that improve life expectancy and quality of life of patients who have neurodegenerative diseases.

Once again the Institute of Catalan Studies is the perfect setting for the scientists who have made breakthroughs in health to meet and exchange knowledge with the society that has made them possible thanks to its support, enthusiasm, confidence and effort.

Single-centre projects
23
Co-ordinated projects
21

Of the 44 projects financed by La Marató 2013, more than half were co-ordinated with two or three research centres led by Catalan teams. This has boosted work by internet and the projection of the results..

PROJECTS

MODULATION OF SYNAPTIC PLASTICITY DEFICITS AS THERAPEUTIC STRATEGY IN HUNTINGTON’S DISEASE

Jordi Alberch Vié
Facultat de Medicina. Universitat de Barcelona
Isabel Pérez Otaño
Universitat Miguel Hernández. Alacant

> Results (in catalan)> Report

ROLE OF NMDA RECEPTORS PHOSPHORYLATION IN ALZHEIMER'S DISEASE AETIOLOGY: FROM PROTEOMICS TO IN VIVO MODELS

Xavier Altafaj Tardio
IDIBELL - Institut d'Investigació Biomèdica de Bellvitge. L'Hospitalet de Llobregat

> Results (in catalan)> Report

SETTING A RATIONAL SCREENING PROGRAMME FOR TRANSTHYRETIN-Aβ BINDING STABILIZING COMPOUNDS THAT MAY LEAD TO POTENTIAL ALZHEIMER’S DISEASE MODULATING DRUGS

Gemma Arsequell Ruiz
Institut Química Avançada de Catalunya - CSIC. Barcelona
Isabel Cardoso
Institute for Molecular Biology and Cell Biology. Porto
Jordi Llop Roig
Asociación Centro de Investigación Coop. Biomateriales - CICbiomaGUNE. Sant Sebastià
Jesús Jiménez Barbero
CIC bioGUNE
Jordi Ramon Quintana Ruiz
Parc Científic de Barcelona - UB. Barcelona

> Results (in catalan)> Report

FREEZING IN PARKINSON'S DISEASE: IMPROVING QUALITY OF LIFE WITH AN AUTOMATIC CONTROL SYSTEM

Àngels Bayés Rusiñol
Centro Médico Teknon. Barcelona
Andreu Català Mallofre
Centre Estudis Tecnològics Dependència i Vida Autònoma - UPC. Vilanova i la Geltrú
Rui Sarmento e Castro
Fraunhofer AICOS - Associaçao Fraunhofer Portugal Research- Porto

> Results (in catalan)> Report

IDENTIFICATION OF SPECIFIC BIOSIGNATURES FROM PLASMA SAMPLES FOR THE DIFFERENTIAL DIAGNOSIS OF DEMENTIA WITH LEWY BODIES

Katrin Beyer
Hospital Universitari Germans Trias i Pujol - FIIGTiP

> Results (in catalan)> Report

TARGETING NEURONAL DOPAMINE D1-HISTAMINE H3 RECEPTOR HETEROMERS AS A NEW TREATMENT OF HUNTINGTON’S DISEASE

Enric I. Canela Campos
Facultat de Biologia. Universitat de Barcelona

> Results (in catalan)> Report

CHARACTERIZATION AND VALIDATION OF A NEW AMYLOID-β OLIGOMER AS A PHARMACOLOGICAL TARGET TO TREAT ALZHEIMER'S DISEASE

Natàlia Carulla Casanova
IRB - Institut Recerca Biomèdica de Barcelona
Serge Muyldermans
Structural Biology Research Center - VIB. Brussels (Belgium)
Giovanni Maglia
University of Leuven (Belgium)

> Results (in catalan)> Report

SYSTEMS BIOMEDICINE FOR UNRAVELING THE MOLECULAR BASIS AND MODELING CORTICOSPINAL MOTOR NEURON DISEASE

Carlos Casasnovas Pons
IDIBELL - Institut d'Investigació Biomèdica de Bellvitge. L'Hospitalet de Llobregat
Maria Jesús Sobrido Gomez
FP Galega de Medicina Xenómica - Fundación Ramon Domínguez. Santiago de Compostela
Cristina Pujades Corbi
Parc de Recerca Biomèdica de Barcelona - UPF. Barcelona
Mariona Jové Font
IRBLL Institut Recerca Biomèdica de Lleida - Fundació Dr. Pifarré

> Results (in catalan)> Report

CHOLESTEROL AND A-INDUCED MITOCHONDRIAL OXIDATIVE STRESS AS A CAUSAL FACTOR AND THERAPEUTIC TARGETS IN ALZHEIMER’S DISEASE

Anna Colell Riera
Institut Investigacions Biomèdiques de BCN - CSIC. Barcelona
Tobias Hartmann
Deutsches Institut für Demenzprävention DID - Saarland University. Hamburg

> Results (in catalan)> Report

BILINGUALISM AS A CONTRIBUTOR TO COGNITIVE RESERVE IN HEALTHY AND PATHOLOGICAL AGEING

Albert Costa Martínez
Centre del Cervell i Cognició - UPF. Barcelona
César Avila River
Facultat de Ciències de la Salut - Universitat Jaume I. Castelló de la Plana

> Results (in catalan)> Report

ROLE OF THE CELLULAR PRION PROTEIN AS “CROSS-TALK” PROTEIN BETWEEN Α-SYN/ LRRK2 AND P-TAU IN SPORADIC AND FAMILIAL PARKINSON’S DISEASE

José Antonio del Rio Fernández
Fundació Institut de Bioenginyeria de Catalunya

> Results> Report

PRONGF/P75NTR SIGNALING IN HIPPOCAMPAL ADULT NEUROGENESIS: POTENTIAL TARGET FOR GENERATING NEW NEURONS IN ALZHEIMER’S DISEASE

Carme Espinet Mestre
IRBLL Institut Recerca Biomèdica de Lleida - Universitat de Lleida

> Results (in catalan)> Report

ALZHEIMER’S DISEASE IN DOWN SYNDROME. CSF, MRI, EEG AND PET MULTIMODAL STUDIES

Juan Fortea Ormaechea
Hospital de la Santa Creu i Sant Pau - IRHSP Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau

> Results (in catalan)> Report

CANNABINOID RECEPTOR HETEROMERIC COMPLEXES AS THERAPEUTIC TARGETS IN PARKINSON’S DISEASE

Rafael Franco Fernández
Facultat de Biologia – Universitat de Barcelona
José Luis Lanciego Pérez
Centro de Investigación Médica Aplicada - FIMANavarra. Pamplona

> Results (in catalan)> Report

DECIPHERING THE LINK BETWEEN ASTROCYTE REACTIVITY AND NEURONAL DAMAGE IN ALZHEIMER'S DISEASE

Elena Galea Rodríguez de Velasco
Institut de Neurociències – Universitat Autònoma de Barcelona
Javier Vitorica Ferrández
Facultat de Farmàcia - Universitat de Sevilla
Antonia Gutiérrez Perez
Facultat de Ciències - Universitat de Màlaga
Joan Xavier Comella Carnicé
VHIR - Institut de Recerca Hospital Universitari Vall d'Hebron

> Results (in catalan)> Report

COGNITIVE TRAINING BASED ON DIGITAL MEMORIES FOR MILD COGNITIVE DETERIORATION (RE-MEMORY)

Maite Garolera Freixa
Hospital de Terrassa - Consorci Sanitari de Terrassa

> Results (in catalan)> Report

PREVALENCE OF ALZHEIMER-TYPE PATHOLOGY IN NON-ALZHEIMER NEURODEGENERATIVE DISORDERS AND ITS IMPLICATION FOR THE DEVELOPMENT OF BIOMARKERS: A BRAIN-BANK-BASED POST-MORTEM STUDY

Ellen Gelpi Mantius
IDIBAPS - Institut d'Investigació Biomèdica August Pi i Sunyer

> Results (in catalan)> Report

DISSECTING PROTEIN TRAFFICKING IN RETINAL NEURODEGENERATION BY SUPER-RESOLUTION IMAGING ON ANIMAL MODELS AND HUMAN IPSCS

Roser Gonzàlez Duarte
Facultat de Biologia. Universitat de Barcelona
Pablo Loza Álvarez
Fundación Pública Andaluza Progreso y Salud - CABIMER. Sevilla
Slaven Erceg
Fundación Pública Andaluza Progreso y Salud - CABIMER. Sevilla

> Results (in catalan)> Report

MOLECULAR IMAGING OF THE RETINA IN PATIENTS WITH MULTIPLE SCLEROSIS BY RAMAN SPECTROSCOPY

Elena Hernández Martínez de Lapiscina
IDIBAPS - Institut d'Investigació Biomèdica August Pi i Sunyer
Pablo Loza Álvarez
ICFO - Institut de Ciències Fotòniques. Castelldefels

> Results (in catalan)> Report

THERAPEUTIC IMPACT OF APOJ/CLUSTERIN-COUPLED LIPOSOMES ON ALZHEIMER'S DISEASE EXPERIMENTAL MODELS

Mar Hernández-Guillamon
VHIR - Institut de Recerca Hospital Universitari Vall d'Hebron

> Results (in catalan)> Report

IDENTIFYING RELIABLE SOURCES OF STEM CELLS FOR CELL REPLACEMENT THERAPY IN RETINAL DEGENERATION DISEASES

Eloisa Herrera González de Molina
Institut de Neurociències d'Alacant - CSIC. Sant Joan d'Alacant
Marta Agudo Barriuso
Instituto Murciano de Investigación Biosanitaria Virgen de la Arrixaca – Fundación para la Formación e Investigación Sanitaria

> Results (in catalan)> Report

ROLE OF IL-6 TRANS-SIGNALING IN A MOUSE MODEL OF ALZHEIMER’S DISEASE

Juan Hidalgo Pareja
Facultat de Biociències. Universitat Autònoma de Barcelona

> Results (in catalan)> Report

BRAIN CONNECTIVITY CHANGES DURING THE DEGENERATIVE PROCESS IN PARKINSON’S DISEASE

Carme Junqué Plaja
IDIBAPS - Institut d'Investigació Biomèdica August Pi i Sunyer

> Results (in catalan)> Report

PREDICTION OF APATHY AND IMPULSE CONTROL DISORDERS IN PARKINSON'S DISEASE BASED ON THE FEEDBACK RELATED NEGATIVITY (FRN), A NEUROPHYSIOLOGICAL MARKER OF INCENTIVE PROCESSING

Jaume Kulisevsky Bojarski
Institut Recerca Hospital de l'Hospital de la Santa Creu i Sant Pau

> Results (in catalan)> Report

NEW TECHNOLOGIES APPLIED TO CLINICAL PRACTICE FOR OBTAINING BIOMARKERS OF ATROPHY AND LESIONS IN MAGNETIC RESONANCE IMAGES OF PATIENTS WITH MULTIPLE SCLEROSIS (BIOMARKEM.CAT)

Xavier Lladó Bardera
Escola Politècnica Superior - Universitat de Girona
Jordi Rio Izquierdo
Centre d'Esclerosi Múltiple de Catalunya CEMCAT - Institut de Recerca de la Vall d'Hebron
Joan Carles Vilanova Busquets
Institut Hospital Dr. Josep Trueta Girona - IDIBGI

> Results (in catalan)> Report

SYNAPTIC MARKERS IN PRECLINICAL ALZHEIMER'S DISEASE

Alberto Lleó Bisa
Hospital de la Santa Creu i Sant Pau - Institut de Recerca HSCiSP

> Results (in catalan)> Report

CATALAN NETWORK OF MULTIPLE SYSTEM ATROPHY: BIOMARKERS AND PATHOPHYSIOLOGY

Josefa Maria Martí Domènech
IDIBAPS - Institut d'Investigació Biomèdica August Pi i Sunyer
Gian Gaetano Tartaglia
Centre de Regulació Genòmica

> Results (in catalan)> Report

GENE THERAPY TARGETING NEUREGULIN FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS

Xavier Navarro Acebes
Facultat de Medicina - Universitat Autònoma de Barcelona

> Results (in catalan)> Report

PLASMA AND NEUROPHYSIOLOGICAL MARKERS OF THE PROGRESSION OF COGNITIVE IMPAIRMENT TO PARKINSON'S DISEASE

Javier Pagonabarraga Mora
Hospital de la Santa Creu i Sant Pau - Institut de Recerca HSCiSP

> Results (in catalan)> Report

CATALAN ADAPTATION AND NORMALITZATION OF NEUROPSYCHOLOGICAL INSTRUMENTS

Jordi Peña Casanova
IMIM - Institut Hospital del Mar d'Investigacions Mèdiques

> Results (in catalan)> Report

NEURODEGENERATION WITH BRAIN IRON ACCUMULATION (NBIA) DISORDERS: CLINICAL EVALUATION AND GENETIC CHARACTERISATION THROUGH A SPANISH MULTICENTRE RESEARCH NETWORK

Belén Pérez Dueñas
VHIR Institut de Recerca Hospital Universitari Vall d'Hebron
Carmen Espinós Armero
Centro de Investigación Príncipe Felipe - CIBERER. València

> Results (in catalan)> Report

IMPACT OF OBSTRUCTIVE SLEEP APNEA IN THE EVOLUTION OF ALZHEIMER DISEASE. ROLE OF HYPOXIA AND SLEEP FRAGMENTATION

Gerard Piñol Ripoll
Hospital de Santa Maria - Institut de Recerca Biomèdica Fundació Dr. Pifarré Lleida
Ramon Farré Ventura
Facultat de Medicina. Universitat de Barcelona
David Gozzal
University of Chicago Medical Center

> Results (in catalan)> Report

THE ROLE OF REELIN AT THE CROSSROADS OF ALZHEIMER'S DISEASE MECHANISMS: TAUOPATHY, AMYLOID TOXICITY AND TRANSMISSIBILITY

Lluís Pujadas Puigdomènech
VHIR Institut de Recerca Hospital Universitari Vall d'Hebron
José María Delgado García
Facultad de ciencias experimentales / Universidad Pablo de Olavide

> Results (in catalan)> Report

CHARACTERIZATION OF NOVEL SUPPRESSORS OF NEURONAL TOXICITY IN MYOTONIC DYSTROPHY TYPE 1

Patricia Robledo Montoya
IMIM - Institut Hospital del Mar d'Investigacions Mèdiques. Barcelona
Manuel Pérez Alonso
Institut de Recerca Sanitària. València

> Results (in catalan)> Report

SEARCHING NEW BIOMARKERS AND THERAPEUTIC TARGETS RELATED TO COGNITIVE DEFICITS IN EARLY STAGES OF ALZHEIMER'S DISEASE: ROLE OF AKAP79/150, CPT1C AND SSAO/VAP-1 IN Aβ-MEDIATED AMPAR DYSFUNCTION

José Rodríguez Álvarez
Institut de Neurociències. Universitat Autònoma de Barcelona

> Results (in catalan)> Report

BIOMARKERS PROFILE IN DIFFERENT MOTOR NEURON DISEASE PHENOTYPES

Ricardo Rojas Garcia
Hospital de la Santa Creu i Sant Pau - Institut de Recerca HSCiSP

> Results (in catalan)> Report

DIAGNOSTIC AND PROGNOSTIC BIOMARKERS IN PEDIATRIC MULTIPLE SCLEROSIS AND RELATED DEMYELINATING DISORDERS

Albert Saiz Hinarejos
Hospital Clínic i Provincial de Barcelona. Fundació Clínic per a la Recerca Biomèdica
Mar Tintoré Subirana
VHIR - Institut de Recerca Hospital Universitari Vall d'Hebron

> Results (in catalan)> Report

STUDY OF GENETIC FRONTOTEMPORAL DEMENTIA IN PRECLINICAL AND EARLY STAGES OF THE DISEASE: COGNITIVE PERFORMANCE, STRUCTURAL AND FUNCTIONAL NEUROIMAGING AND BIOCHEMICAL MARKERS

Raquel Sánchez del Valle Díaz
IDIBAPS - Institut d'Investigació Biomèdica August Pi i Sunyer

> Results (in catalan)> Report

ICTAL SPECT IN THE PARKINSON PREMOTOR PHASE OF STUDY

Joan Santamaria Cano
IDIBAPS - Institut d'Investigació Biomèdica August Pi i Sunyer

> Results (in catalan)> Report

NEW STEM CELL THERAPIES FOR DUCHENE MUSCULAR DYSTROPHY

Antonio L. Serrano Sánchez
Facultat Ciències Salut i Vida – UPF, Barcelona
Francesco Saverio Tedesco
Cell and Developmental Biology - University College, London
Giulio Cossu
Centre For Tissue Injury and Repair - University of Manchester (UK)

> Results (in catalan)> Report

MRI BRAIN CONNECTOMICS AND METABOLIC IMAGING IN THE TGF344-AD RAT: A NEW APPROACH FOR THE STUDY OF ALZHEIMER'S DISEASE

Guadalupe Soria Rodríguez
IDIBAPS - Institut d'Investigació Biomèdica August Pi i Sunyer

> Results (in catalan)> Report

PRECLINICAL TESTING OF DRUGS AGAINST THE TOXIC EFFECTS OF MUTANT HUNTINGTIN IN MURINE MODELS OF HD

Rafael Vázquez-Manrique
Hospital Universitari i Politècnic La Fe. València

> Results (in catalan)> Report

DECIPHERING THE ROLE OF ALPHA-SYNUCLEIN STRAINS IN PRION-LIKE SYNUCLEINOPATHY INDUCTION AND SPREADING

Salvador Ventura Zamora
Institut Biotecnologia i Biomedicina – UAB, Bellaterra
Tiago Outeiro
University Medical Center Göttingen (Alemanya)
Juan Maria Torres Trillo
Centro de Investigación en Sanidad Animal - Instituto Nacional de Investigación y Tecnologia Agraria y Alimentaria. Valdeolmos (Madrid)

> Results (in catalan)> Report

EVALUATION OF AN INNOVATIVE INTERVENTION (INFORMATIVE, FORMATIVE AND OF SOCIAL SUPPORT) "INFOSA-DEM" TO INFORMAL CAREGIVERS OF PEOPLE WITH DEMENTIA LIVING AT HOME

Adelaida Zabalegui Yárnoz
Hospital Clínic i Provincial de Barcelona - Fundació Clínic per a la Recerca Biomèdica

> Results (in catalan)> Report

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